Drug interactions
Bosutinib + Isoniazid
Severity: Moderate
Bosutinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and increase bosutinib exposure, raising the risk of gastrointestinal toxicity, hepatotoxicity and myelosuppression. Isoniazid is a weaker inhibitor than potent agents, so the magnitude is uncertain.
What this interaction means in plain words
Bosutinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, decreasing the metabolism of bosutinib.
What to do
Monitor liver tests, blood counts and diarrhea, and reduce the bosutinib dose if toxicity develops. Consider an alternative antituberculous option when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Isoniazid?
MediHelp rates the interaction as moderate. Bosutinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and increase bosutinib exposure, raising the risk of gastrointestinal toxicity, hepatotoxicity and myelosuppression. Isoniazid is a weaker inhibitor than potent agents, so the magnitude is uncertain.
How serious is the interaction between Bosutinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests, blood counts and diarrhea, and reduce the bosutinib dose if toxicity develops. Consider an alternative antituberculous option when feasible.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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