Drug interactions
Bosutinib + Lansoprazole
Severity: Moderate
Bosutinib and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib solubility falls as pH rises, so PPIs can reduce its absorption and exposure. This may compromise efficacy in leukemia treatment.
What this interaction means in plain words
Bosutinib and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces the solubility and absorption of bosutinib.
What to do
Avoid PPIs where possible; consider short-acting antacids or H2 blockers separated from bosutinib dosing, and monitor molecular response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Lansoprazole?
MediHelp rates the interaction as moderate. Bosutinib and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib solubility falls as pH rises, so PPIs can reduce its absorption and exposure. This may compromise efficacy in leukemia treatment.
How serious is the interaction between Bosutinib and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs where possible; consider short-acting antacids or H2 blockers separated from bosutinib dosing, and monitor molecular response.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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