Drug interactions
Bosutinib + Metronidazole
Severity: Minor
Bosutinib and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is not a clinically significant CYP3A4 inhibitor, so a meaningful increase in bosutinib exposure is unlikely. Bosutinib toxicity such as diarrhea and liver enzyme elevation remains possible, but is not predictably increased.
What this interaction means in plain words
Bosutinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole; not well established.
What to do
No routine dose change; monitor liver enzymes and gastrointestinal tolerance as usual for bosutinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Metronidazole?
MediHelp rates the interaction as minor. Bosutinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is not a clinically significant CYP3A4 inhibitor, so a meaningful increase in bosutinib exposure is unlikely. Bosutinib toxicity such as diarrhea and liver enzyme elevation remains possible, but is not predictably increased.
How serious is the interaction between Bosutinib and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor liver enzymes and gastrointestinal tolerance as usual for bosutinib.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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