Drug interactions
Bosutinib + Rabeprazole
Severity: Moderate
Bosutinib and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib dissolves less well at higher pH, and PPIs can lower its exposure, which may compromise leukemia control. The label advises considering short-acting antacids or H2 blockers instead of PPIs.
What this interaction means in plain words
Bosutinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces bosutinib solubility and absorption.
What to do
Avoid rabeprazole where possible; use a short-acting antacid or H2 blocker separated from bosutinib by several hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Rabeprazole?
MediHelp rates the interaction as moderate. Bosutinib and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosutinib dissolves less well at higher pH, and PPIs can lower its exposure, which may compromise leukemia control. The label advises considering short-acting antacids or H2 blockers instead of PPIs.
How serious is the interaction between Bosutinib and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rabeprazole where possible; use a short-acting antacid or H2 blocker separated from bosutinib by several hours.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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