Drug interactions
Brentuximab + Cholera vaccine
Severity: Moderate
Brentuximab and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brentuximab vedotin is a cytotoxic antibody-drug conjugate that can cause myelosuppression, so the antibody response to an oral cholera vaccine may be blunted. Protection against cholera may therefore be lower than expected.
What this interaction means in plain words
Brentuximab and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and lymphocyte reduction impair the vaccine immune response.
What to do
If feasible, vaccinate at least 2 weeks before starting therapy or defer until immune recovery. Maintain hygiene precautions if traveling to endemic areas.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brentuximab and Cholera vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Frequently asked questions
Can I take Brentuximab with Cholera vaccine?
MediHelp rates the interaction as moderate. Brentuximab and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brentuximab vedotin is a cytotoxic antibody-drug conjugate that can cause myelosuppression, so the antibody response to an oral cholera vaccine may be blunted. Protection against cholera may therefore be lower than expected.
How serious is the interaction between Brentuximab and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If feasible, vaccinate at least 2 weeks before starting therapy or defer until immune recovery. Maintain hygiene precautions if traveling to endemic areas.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
