Drug interactions
Bleomycin + Brentuximab
Severity: Contraindicated
Bleomycin and Brentuximab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bleomycin causes dose-related pulmonary toxicity, and adding brentuximab vedotin has led to excess pulmonary injury in Hodgkin lymphoma regimens. Cough, dyspnoea and fatal respiratory failure are recorded.
What this interaction means in plain words
Bleomycin and Brentuximab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bleomycin belongs to Oncology; Brentuximab belongs to Oncology.
Why it happens
Additive pulmonary toxicity
What to do
Do not use bleomycin together with brentuximab vedotin; use a bleomycin-free regimen (for example AVD with brentuximab) and report new respiratory symptoms promptly.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Brentuximab
Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
- Bleomycin + Ethotoin Moderate
Frequently asked questions
Can I take Bleomycin with Brentuximab?
MediHelp rates the interaction as contraindicated. Bleomycin and Brentuximab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bleomycin causes dose-related pulmonary toxicity, and adding brentuximab vedotin has led to excess pulmonary injury in Hodgkin lymphoma regimens. Cough, dyspnoea and fatal respiratory failure are recorded.
How serious is the interaction between Bleomycin and Brentuximab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use bleomycin together with brentuximab vedotin; use a bleomycin-free regimen (for example AVD with brentuximab) and report new respiratory symptoms promptly.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Dengue vaccine, Etrasimod, Idelalisib. The full list is on the Brentuximab page.
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