Drug interactions
Brentuximab + Etrasimod
Severity: Major
Brentuximab and Etrasimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brentuximab vedotin is cytotoxic and can cause neutropenia and serious infections, while etrasimod reduces circulating lymphocytes. Together they may add to infection risk, and etrasimod labeling advises against combining it with antineoplastic therapies. Effects of etrasimod persist for weeks after discontinuation.
What this interaction means in plain words
Brentuximab and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from myelosuppression due to the brentuximab vedotin payload and lymphocyte sequestration due to etrasimod.
What to do
Avoid combining where an alternative exists, including for weeks after stopping etrasimod. If unavoidable, monitor blood counts and watch for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
- Brentuximab + Ritonavir Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Brentuximab with Etrasimod?
MediHelp rates the interaction as major. Brentuximab and Etrasimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brentuximab vedotin is cytotoxic and can cause neutropenia and serious infections, while etrasimod reduces circulating lymphocytes. Together they may add to infection risk, and etrasimod labeling advises against combining it with antineoplastic therapies. Effects of etrasimod persist for weeks after discontinuation.
How serious is the interaction between Brentuximab and Etrasimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where an alternative exists, including for weeks after stopping etrasimod. If unavoidable, monitor blood counts and watch for infection.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Idelalisib. The full list is on the Brentuximab page.
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