Drug interactions
Brentuximab + Fexinidazole
Severity: Moderate
Brentuximab and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4, and MMAE, the cytotoxic component of brentuximab vedotin, is metabolized by CYP3A4. Increased MMAE exposure may increase neutropenia and neuropathy. Fexinidazole is used only for short courses for trypanosomiasis, so the overlap would be brief.
What this interaction means in plain words
Brentuximab and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by fexinidazole may decrease MMAE clearance.
What to do
Avoid if possible and defer brentuximab if the fexinidazole course is short. If both are needed, monitor blood counts and neuropathy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Frequently asked questions
Can I take Brentuximab with Fexinidazole?
MediHelp rates the interaction as moderate. Brentuximab and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4, and MMAE, the cytotoxic component of brentuximab vedotin, is metabolized by CYP3A4. Increased MMAE exposure may increase neutropenia and neuropathy. Fexinidazole is used only for short courses for trypanosomiasis, so the overlap would be brief.
How serious is the interaction between Brentuximab and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and defer brentuximab if the fexinidazole course is short. If both are needed, monitor blood counts and neuropathy.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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