Drug interactions
Brentuximab + Fosamprenavir
Severity: Moderate
Brentuximab and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, via its active metabolite amprenavir, inhibits CYP3A4 and can increase exposure to MMAE released from brentuximab vedotin. This raises the risk of neutropenia and peripheral neuropathy.
What this interaction means in plain words
Brentuximab and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Amprenavir inhibition of CYP3A4 reduces MMAE metabolic clearance.
What to do
Monitor complete blood counts and neuropathy symptoms closely. Delay, reduce or stop brentuximab if significant neutropenia or neuropathy occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brentuximab and Fosamprenavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Frequently asked questions
Can I take Brentuximab with Fosamprenavir?
MediHelp rates the interaction as moderate. Brentuximab and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, via its active metabolite amprenavir, inhibits CYP3A4 and can increase exposure to MMAE released from brentuximab vedotin. This raises the risk of neutropenia and peripheral neuropathy.
How serious is the interaction between Brentuximab and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and neuropathy symptoms closely. Delay, reduce or stop brentuximab if significant neutropenia or neuropathy occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
