Drug interactions
Brentuximab + Phenytoin
Severity: Minor
Brentuximab and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin is a potent CYP3A4 inducer and may lower exposure to the active cytotoxic component of brentuximab vedotin (MMAE). This could reduce antitumor effect, although no dedicated clinical outcome data exist.
What this interaction means in plain words
Brentuximab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by phenytoin may increase clearance of MMAE, the CYP3A4 substrate released from brentuximab vedotin.
What to do
Prefer a non-inducing anticonvulsant such as levetiracetam where feasible. If phenytoin is required, monitor tumor response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Brentuximab with Phenytoin?
MediHelp rates the interaction as minor. Brentuximab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin is a potent CYP3A4 inducer and may lower exposure to the active cytotoxic component of brentuximab vedotin (MMAE). This could reduce antitumor effect, although no dedicated clinical outcome data exist.
How serious is the interaction between Brentuximab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant such as levetiracetam where feasible. If phenytoin is required, monitor tumor response.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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