Drug interactions
Brentuximab + Rifampin
Severity: Moderate
Brentuximab and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong CYP3A4 inducer. In a pharmacokinetic study it lowered exposure to MMAE released from brentuximab vedotin, which may reduce efficacy.
What this interaction means in plain words
Brentuximab and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induction of CYP3A4 accelerates MMAE clearance.
What to do
Avoid combination where an alternative is available and monitor tumor response if rifampin is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Frequently asked questions
Can I take Brentuximab with Rifampin?
MediHelp rates the interaction as moderate. Brentuximab and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong CYP3A4 inducer. In a pharmacokinetic study it lowered exposure to MMAE released from brentuximab vedotin, which may reduce efficacy.
How serious is the interaction between Brentuximab and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where an alternative is available and monitor tumor response if rifampin is required.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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