Drug interactions
Brentuximab vedotin + Phenytoin
Severity: Minor
Brentuximab vedotin and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, a strong CYP3A4 inducer, may reduce exposure to the cytotoxic payload of brentuximab vedotin (MMAE), which is a CYP3A4 substrate. The clinical impact is likely modest because the effect on unconjugated MMAE is the main concern and intact antibody-drug conjugate is not affected.
What this interaction means in plain words
Brentuximab vedotin and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brentuximab vedotin belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
CYP3A4 induction by phenytoin may increase clearance of free MMAE released from the conjugate.
What to do
No dose change is generally required; monitor for reduced antitumor response when strong inducers are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Imatinib Moderate
- Brentuximab vedotin + Isoniazid Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Phenytoin?
MediHelp rates the interaction as minor. Brentuximab vedotin and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin, a strong CYP3A4 inducer, may reduce exposure to the cytotoxic payload of brentuximab vedotin (MMAE), which is a CYP3A4 substrate. The clinical impact is likely modest because the effect on unconjugated MMAE is the main concern and intact antibody-drug conjugate is not affected.
How serious is the interaction between Brentuximab vedotin and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for reduced antitumor response when strong inducers are used long term.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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