Drug interactions
Brentuximab vedotin + Imatinib
Severity: Moderate
Brentuximab vedotin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and may raise exposure to MMAE released from brentuximab vedotin. This could worsen neutropenia and neuropathy.
What this interaction means in plain words
Brentuximab vedotin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab vedotin belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by imatinib reduces MMAE clearance.
What to do
Monitor blood counts and neuropathy symptoms, and consider dose delay for neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Brentuximab vedotin
- Bleomycin + Brentuximab vedotin Contraindicated
- Brentuximab vedotin + Siponimod Major
- Apalutamide + Brentuximab vedotin Moderate
- Brentuximab vedotin + Clarithromycin Moderate
- Brentuximab vedotin + Isoniazid Moderate
- Brentuximab vedotin + Itraconazole Moderate
Frequently asked questions
Can I take Brentuximab vedotin with Imatinib?
MediHelp rates the interaction as moderate. Brentuximab vedotin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a moderate CYP3A4 inhibitor and may raise exposure to MMAE released from brentuximab vedotin. This could worsen neutropenia and neuropathy.
How serious is the interaction between Brentuximab vedotin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms, and consider dose delay for neutropenia.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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