Drug interactions
Bretylium + Hydrochlorothiazide-losartan
Severity: Moderate
Bretylium and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium can cause marked hypotension, and combining it with losartan and hydrochlorothiazide can worsen this effect. Diuretic-induced volume or potassium depletion may also raise arrhythmia risk.
What this interaction means in plain words
Bretylium and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from adrenergic neuron blockade and RAAS blockade plus diuresis.
What to do
Monitor blood pressure closely and correct potassium and volume status; reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Bretylium with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Bretylium and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium can cause marked hypotension, and combining it with losartan and hydrochlorothiazide can worsen this effect. Diuretic-induced volume or potassium depletion may also raise arrhythmia risk.
How serious is the interaction between Bretylium and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and correct potassium and volume status; reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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