Drug interactions
Bretylium + Nadolol
Severity: Moderate
Bretylium and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension, and nadolol may add to this effect. The combination may also dampen the expected cardiovascular responses.
What this interaction means in plain words
Bretylium and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from adrenergic neuron blockade and beta-blockade.
What to do
Monitor blood pressure and heart rate closely when bretylium is given to patients on nadolol, and adjust doses or fluids if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Frequently asked questions
Can I take Bretylium with Nadolol?
MediHelp rates the interaction as moderate. Bretylium and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension, and nadolol may add to this effect. The combination may also dampen the expected cardiovascular responses.
How serious is the interaction between Bretylium and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely when bretylium is given to patients on nadolol, and adjust doses or fluids if hypotension occurs.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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