Drug interactions
Bretylium + Nimodipine
Severity: Moderate
Bretylium and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, and combined use may cause additive or profound hypotension. Bretylium causes adrenergic neuron blockade and orthostatic hypotension, while nimodipine vasodilates.
What this interaction means in plain words
Bretylium and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects through adrenergic neuron blockade and calcium channel blockade.
What to do
Monitor blood pressure closely, including orthostatic changes, and reduce doses or hold nimodipine if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bretylium and Nimodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Bretylium with Nimodipine?
MediHelp rates the interaction as moderate. Bretylium and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, and combined use may cause additive or profound hypotension. Bretylium causes adrenergic neuron blockade and orthostatic hypotension, while nimodipine vasodilates.
How serious is the interaction between Bretylium and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, including orthostatic changes, and reduce doses or hold nimodipine if hypotension develops.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
