Drug interactions
Bretylium + Procarbazine
Severity: Major
Bretylium and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting activity, and MAO inhibition can potentiate the catecholamine release produced by bretylium. This may cause hypertension, tachycardia, or arrhythmias.
What this interaction means in plain words
Bretylium and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition by procarbazine prolongs the action of catecholamines released by bretylium.
What to do
Avoid the combination where possible. If bretylium is essential, monitor blood pressure and ECG continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Bretylium with Procarbazine?
MediHelp rates the interaction as major. Bretylium and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has monoamine oxidase inhibiting activity, and MAO inhibition can potentiate the catecholamine release produced by bretylium. This may cause hypertension, tachycardia, or arrhythmias.
How serious is the interaction between Bretylium and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If bretylium is essential, monitor blood pressure and ECG continuously.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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