Drug interactions
Bretylium + Verapamil
Severity: Moderate
Bretylium and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, and together they may cause significant hypotension. Bretylium also causes adrenergic neuron blockade, which can worsen orthostatic effects.
What this interaction means in plain words
Bretylium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from calcium channel blockade and adrenergic neuron blockade.
What to do
Monitor blood pressure and ECG continuously during co-administration and be ready to give fluids or vasopressors; reduce doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Bretylium with Verapamil?
MediHelp rates the interaction as moderate. Bretylium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, and together they may cause significant hypotension. Bretylium also causes adrenergic neuron blockade, which can worsen orthostatic effects.
How serious is the interaction between Bretylium and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and ECG continuously during co-administration and be ready to give fluids or vasopressors; reduce doses if hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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