Drug interactions
Brexanolone + Brompheniramine
Severity: Moderate
Brexanolone and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and other CNS depressants such as sedating antihistamines can add to this. The combination increases the risk of impaired consciousness and respiratory compromise.
What this interaction means in plain words
Brexanolone and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A positive modulation plus histamine H1 blockade.
What to do
Monitor sedation level and pulse oximetry continuously during the brexanolone infusion. Consider holding brompheniramine or reducing its dose during the infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Brexanolone with Brompheniramine?
MediHelp rates the interaction as moderate. Brexanolone and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness, and other CNS depressants such as sedating antihistamines can add to this. The combination increases the risk of impaired consciousness and respiratory compromise.
How serious is the interaction between Brexanolone and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and pulse oximetry continuously during the brexanolone infusion. Consider holding brompheniramine or reducing its dose during the infusion.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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