Drug interactions
Brexanolone + Levetiracetam
Severity: Moderate
Brexanolone and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and levetiracetam also causes somnolence. Combined use may increase the risk and degree of sedation.
What this interaction means in plain words
Brexanolone and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from a GABA-A positive modulator and levetiracetam.
What to do
Monitor sedation and pulse oximetry continuously during the brexanolone infusion, as required by its labeling. Interrupt or reduce the infusion if excessive sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Brexanolone with Levetiracetam?
MediHelp rates the interaction as moderate. Brexanolone and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes excessive sedation and sudden loss of consciousness, and levetiracetam also causes somnolence. Combined use may increase the risk and degree of sedation.
How serious is the interaction between Brexanolone and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and pulse oximetry continuously during the brexanolone infusion, as required by its labeling. Interrupt or reduce the infusion if excessive sedation develops.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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