Drug interactions
Brexanolone + Metaxalone
Severity: Moderate
Brexanolone and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone infusion causes excessive sleepiness and sedation, and its labeling advises caution with other CNS depressants. Metaxalone may intensify this effect.
What this interaction means in plain words
Brexanolone and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; brexanolone is a GABA-A positive modulator.
What to do
Monitor sedation and oxygen saturation throughout the infusion. Consider holding or reducing metaxalone during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Brexanolone with Metaxalone?
MediHelp rates the interaction as moderate. Brexanolone and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone infusion causes excessive sleepiness and sedation, and its labeling advises caution with other CNS depressants. Metaxalone may intensify this effect.
How serious is the interaction between Brexanolone and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation throughout the infusion. Consider holding or reducing metaxalone during treatment.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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