Drug interactions
Brimonidine + Chloral hydrate
Severity: Minor
Brimonidine and Chloral hydrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine, an alpha-2 agonist, can cause drowsiness and fatigue, which may add to chloral hydrate sedation. With ophthalmic use systemic exposure is low, so the effect is usually modest, though it may matter in infants and children.
What this interaction means in plain words
Brimonidine and Chloral hydrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Chloral hydrate belongs to Central Nervous System.
Why it happens
Additive CNS depression from systemic alpha-2 agonist absorption and chloral hydrate.
What to do
Usually no change is needed in adults; observe for excess sedation. Be especially watchful in young children given chloral hydrate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Chloral hydrate?
MediHelp rates the interaction as minor. Brimonidine and Chloral hydrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine, an alpha-2 agonist, can cause drowsiness and fatigue, which may add to chloral hydrate sedation. With ophthalmic use systemic exposure is low, so the effect is usually modest, though it may matter in infants and children.
How serious is the interaction between Brimonidine and Chloral hydrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed in adults; observe for excess sedation. Be especially watchful in young children given chloral hydrate.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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