Drug interactions
Brimonidine + Clonazepam
Severity: Minor
Brimonidine and Clonazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops have low systemic absorption but can cause drowsiness in some patients, which may add to clonazepam sedation. The effect is usually small, and is more relevant in children, who are more sensitive.
What this interaction means in plain words
Brimonidine and Clonazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from systemic alpha-2 agonism by absorbed brimonidine and GABA-A potentiation by clonazepam.
What to do
Be aware of increased drowsiness, especially in children and the elderly. Counsel patients on caution when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Clonazepam?
MediHelp rates the interaction as minor. Brimonidine and Clonazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops have low systemic absorption but can cause drowsiness in some patients, which may add to clonazepam sedation. The effect is usually small, and is more relevant in children, who are more sensitive.
How serious is the interaction between Brimonidine and Clonazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of increased drowsiness, especially in children and the elderly. Counsel patients on caution when driving.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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