Drug interactions
Brimonidine + Diazepam
Severity: Minor
Brimonidine and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine as an eye drop has low systemic absorption, but some systemic exposure can cause drowsiness and fatigue. Used with diazepam this may add modestly to sedation.
What this interaction means in plain words
Brimonidine and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression from systemic alpha-2 agonist activity of brimonidine combined with GABA-A potentiation by diazepam.
What to do
No routine change is needed for ophthalmic use; ask patients about unusual drowsiness and counsel on driving. Use nasal occlusion after instilling drops to limit systemic uptake.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Diazepam?
MediHelp rates the interaction as minor. Brimonidine and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine as an eye drop has low systemic absorption, but some systemic exposure can cause drowsiness and fatigue. Used with diazepam this may add modestly to sedation.
How serious is the interaction between Brimonidine and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for ophthalmic use; ask patients about unusual drowsiness and counsel on driving. Use nasal occlusion after instilling drops to limit systemic uptake.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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