Drug interactions
Brimonidine + Eprosartan-hydrochlorothiazide
Severity: Minor
Brimonidine and Eprosartan-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause systemic hypotension when absorbed, though ophthalmic absorption is limited. It may add slightly to the blood pressure lowering of eprosartan and hydrochlorothiazide, with dizziness in susceptible patients.
What this interaction means in plain words
Brimonidine and Eprosartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from alpha-2 agonist central sympatholytic effect with antihypertensive therapy.
What to do
Monitor blood pressure and orthostatic symptoms in susceptible patients, particularly the elderly. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as minor. Brimonidine and Eprosartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can cause systemic hypotension when absorbed, though ophthalmic absorption is limited. It may add slightly to the blood pressure lowering of eprosartan and hydrochlorothiazide, with dizziness in susceptible patients.
How serious is the interaction between Brimonidine and Eprosartan-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms in susceptible patients, particularly the elderly. No routine dose change is needed.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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