Drug interactions
Brimonidine + Hydralazine
Severity: Minor
Brimonidine and Hydralazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine can lower blood pressure through systemic absorption, possibly adding to the effect of hydralazine. With ophthalmic use the effect is usually small.
What this interaction means in plain words
Brimonidine and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Hydralazine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from central alpha-2 agonism and direct arteriolar vasodilation.
What to do
No routine adjustment is needed. Monitor blood pressure if the patient reports dizziness or lightheadedness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Hydralazine?
MediHelp rates the interaction as minor. Brimonidine and Hydralazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine can lower blood pressure through systemic absorption, possibly adding to the effect of hydralazine. With ophthalmic use the effect is usually small.
How serious is the interaction between Brimonidine and Hydralazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure if the patient reports dizziness or lightheadedness.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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