Drug interactions
Brimonidine + Imipramine
Severity: Minor
Brimonidine and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops are absorbed systemically to a small degree and can cause drowsiness. Combined with sedating imipramine, additive somnolence is possible. Tricyclics may also blunt the blood pressure effect of alpha-2 agonists, though this is uncommon with ophthalmic use.
What this interaction means in plain words
Brimonidine and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression; tricyclics may antagonize alpha-2 agonist effects.
What to do
Counsel about drowsiness. Monitor for reduced intraocular pressure response and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Imipramine?
MediHelp rates the interaction as minor. Brimonidine and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops are absorbed systemically to a small degree and can cause drowsiness. Combined with sedating imipramine, additive somnolence is possible. Tricyclics may also blunt the blood pressure effect of alpha-2 agonists, though this is uncommon with ophthalmic use.
How serious is the interaction between Brimonidine and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness. Monitor for reduced intraocular pressure response and sedation.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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