Drug interactions
Brimonidine + Lisinopril
Severity: Minor
Brimonidine and Lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an ophthalmic alpha-2 agonist with low systemic absorption from eye drops, and any hypotensive effect is small. The combination with lisinopril is unlikely to be clinically important.
What this interaction means in plain words
Brimonidine and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Lisinopril belongs to Cardiovascular.
Why it happens
Possible small additive blood pressure lowering from systemically absorbed brimonidine.
What to do
No routine action needed; check blood pressure if the patient reports dizziness after starting brimonidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Lisinopril?
MediHelp rates the interaction as minor. Brimonidine and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an ophthalmic alpha-2 agonist with low systemic absorption from eye drops, and any hypotensive effect is small. The combination with lisinopril is unlikely to be clinically important.
How serious is the interaction between Brimonidine and Lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed; check blood pressure if the patient reports dizziness after starting brimonidine.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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