Drug interactions
Brimonidine + Lorazepam
Severity: Minor
Brimonidine and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops are minimally absorbed systemically and rarely cause meaningful sedation, though drowsiness is reported. Any additive effect with lorazepam is likely small.
What this interaction means in plain words
Brimonidine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Lorazepam belongs to Central Nervous System.
Why it happens
Possible additive CNS depression via alpha-2 agonism after small systemic absorption.
What to do
No routine change is needed. Warn patients about drowsiness, particularly in children and older adults, and review therapy if it is excessive.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Lorazepam?
MediHelp rates the interaction as minor. Brimonidine and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops are minimally absorbed systemically and rarely cause meaningful sedation, though drowsiness is reported. Any additive effect with lorazepam is likely small.
How serious is the interaction between Brimonidine and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Warn patients about drowsiness, particularly in children and older adults, and review therapy if it is excessive.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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