Drug interactions
Brimonidine + Methadone
Severity: Minor
Brimonidine and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops have little systemic exposure, though they can occasionally cause drowsiness and lower blood pressure. A meaningful sedative interaction with methadone is unlikely with ophthalmic use.
What this interaction means in plain words
Brimonidine and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Methadone belongs to Musculoskeletal.
Why it happens
Possible additive CNS depression through alpha-2 agonism, limited by low systemic absorption.
What to do
No action is generally needed; counsel the patient about possible drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Methadone?
MediHelp rates the interaction as minor. Brimonidine and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops have little systemic exposure, though they can occasionally cause drowsiness and lower blood pressure. A meaningful sedative interaction with methadone is unlikely with ophthalmic use.
How serious is the interaction between Brimonidine and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; counsel the patient about possible drowsiness.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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