Drug interactions
Brimonidine + Morphine
Severity: Minor
Brimonidine and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist with sedative effects, and systemic absorption can add to morphine-induced drowsiness. With ophthalmic use the effect is usually small, but it may matter in children or older adults.
What this interaction means in plain words
Brimonidine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from alpha-2 adrenergic agonism and opioid receptor agonism.
What to do
Monitor for excess drowsiness, particularly in elderly patients or when morphine doses are high. Counsel about driving and other tasks requiring alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Morphine?
MediHelp rates the interaction as minor. Brimonidine and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist with sedative effects, and systemic absorption can add to morphine-induced drowsiness. With ophthalmic use the effect is usually small, but it may matter in children or older adults.
How serious is the interaction between Brimonidine and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness, particularly in elderly patients or when morphine doses are high. Counsel about driving and other tasks requiring alertness.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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