Drug interactions
Brimonidine + Propranolol
Severity: Minor
Brimonidine and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine eye drops are absorbed to a small extent and may lower blood pressure and heart rate slightly. This could add to the effect of propranolol, though clinically important changes are uncommon.
What this interaction means in plain words
Brimonidine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Propranolol belongs to Cardiovascular.
Why it happens
Additive hypotensive and bradycardic effects from systemic alpha-2 agonism and beta blockade.
What to do
No change is usually needed; check blood pressure and pulse if the patient reports dizziness or fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Propranolol?
MediHelp rates the interaction as minor. Brimonidine and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine eye drops are absorbed to a small extent and may lower blood pressure and heart rate slightly. This could add to the effect of propranolol, though clinically important changes are uncommon.
How serious is the interaction between Brimonidine and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed; check blood pressure and pulse if the patient reports dizziness or fatigue.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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