Drug interactions
Brimonidine + Sacubitril-valsartan
Severity: Minor
Brimonidine and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine, an alpha-2 agonist, can lower blood pressure through systemic absorption, particularly with ophthalmic use, but systemic exposure is generally small. Any additive hypotensive effect with sacubitril/valsartan is expected to be minor.
What this interaction means in plain words
Brimonidine and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Alpha-2 adrenergic agonism may add to blood pressure lowering from angiotensin receptor and neprilysin inhibition.
What to do
No routine action needed. Monitor blood pressure if the patient reports dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Brimonidine and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine, an alpha-2 agonist, can lower blood pressure through systemic absorption, particularly with ophthalmic use, but systemic exposure is generally small. Any additive hypotensive effect with sacubitril/valsartan is expected to be minor.
How serious is the interaction between Brimonidine and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action needed. Monitor blood pressure if the patient reports dizziness.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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