Drug interactions
Brimonidine + Scopolamine
Severity: Minor
Brimonidine and Scopolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine has central alpha-2 agonist activity that can cause drowsiness, and scopolamine is also sedating. Together they may increase sleepiness and impair alertness. Systemic exposure from ophthalmic brimonidine is limited, so the effect is usually modest.
What this interaction means in plain words
Brimonidine and Scopolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Scopolamine belongs to Respiratory.
Why it happens
Additive central nervous system depressant effects from alpha-2 agonism and central muscarinic blockade.
What to do
Advise patients to watch for excess drowsiness and to avoid driving until they know how they respond. Reduce the dose of one agent if sedation becomes troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Scopolamine
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Scopolamine?
MediHelp rates the interaction as minor. Brimonidine and Scopolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine has central alpha-2 agonist activity that can cause drowsiness, and scopolamine is also sedating. Together they may increase sleepiness and impair alertness. Systemic exposure from ophthalmic brimonidine is limited, so the effect is usually modest.
How serious is the interaction between Brimonidine and Scopolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and to avoid driving until they know how they respond. Reduce the dose of one agent if sedation becomes troublesome.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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