Drug interactions
Brimonidine + Valsartan
Severity: Minor
Brimonidine and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine as an ophthalmic agent has low systemic absorption, but systemic alpha-2 agonist effects can occasionally cause hypotension and bradycardia. A small additive effect with valsartan is conceivable.
What this interaction means in plain words
Brimonidine and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Valsartan belongs to Cardiovascular.
Why it happens
Additive hypotension from central alpha-2 agonism and angiotensin receptor blockade after systemic absorption.
What to do
Monitor blood pressure if the patient reports dizziness after starting brimonidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Valsartan?
MediHelp rates the interaction as minor. Brimonidine and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine as an ophthalmic agent has low systemic absorption, but systemic alpha-2 agonist effects can occasionally cause hypotension and bradycardia. A small additive effect with valsartan is conceivable.
How serious is the interaction between Brimonidine and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if the patient reports dizziness after starting brimonidine.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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