Drug interactions
Brivaracetam + Chlorzoxazone
Severity: Moderate
Brivaracetam and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam frequently causes somnolence and dizziness, and chlorzoxazone may add to these effects. This can reduce alertness and increase the risk of falls.
What this interaction means in plain words
Brivaracetam and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and dizziness, particularly after dose changes. Counsel on driving and consider lowering the chlorzoxazone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Chlorzoxazone?
MediHelp rates the interaction as moderate. Brivaracetam and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam frequently causes somnolence and dizziness, and chlorzoxazone may add to these effects. This can reduce alertness and increase the risk of falls.
How serious is the interaction between Brivaracetam and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, particularly after dose changes. Counsel on driving and consider lowering the chlorzoxazone dose if needed.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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