Drug interactions
Brivaracetam + Desipramine
Severity: Moderate
Brivaracetam and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and impaired concentration, so sedation may be additive. No significant pharmacokinetic interaction is expected, although tricyclics can lower seizure threshold.
What this interaction means in plain words
Brivaracetam and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Desipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel patients about impaired alertness and driving; monitor for sedation and seizure control, adjusting doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Desipramine?
MediHelp rates the interaction as moderate. Brivaracetam and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, dizziness and impaired concentration, so sedation may be additive. No significant pharmacokinetic interaction is expected, although tricyclics can lower seizure threshold.
How serious is the interaction between Brivaracetam and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about impaired alertness and driving; monitor for sedation and seizure control, adjusting doses if needed.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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