Drug interactions
Brivaracetam + Doxepin
Severity: Moderate
Brivaracetam and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, especially at low doses used for insomnia. With brivaracetam, drowsiness and impaired psychomotor function may increase, and tricyclics may lower the seizure threshold.
What this interaction means in plain words
Brivaracetam and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression, with a pharmacodynamic opposition to anticonvulsant effect from tricyclic pro-convulsant properties.
What to do
Monitor for oversedation and any change in seizure frequency. Use the lowest effective doxepin dose and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Brivaracetam with Doxepin?
MediHelp rates the interaction as moderate. Brivaracetam and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, especially at low doses used for insomnia. With brivaracetam, drowsiness and impaired psychomotor function may increase, and tricyclics may lower the seizure threshold.
How serious is the interaction between Brivaracetam and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and any change in seizure frequency. Use the lowest effective doxepin dose and counsel on driving.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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