Drug interactions
Brivaracetam + Maprotiline
Severity: Moderate
Brivaracetam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness. Maprotiline also lowers the seizure threshold, which may oppose the anticonvulsant effect of brivaracetam.
What this interaction means in plain words
Brivaracetam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression and pharmacodynamic opposition on seizure threshold.
What to do
Monitor seizure control and sedation. Consider a safer antidepressant in patients with epilepsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Maprotiline?
MediHelp rates the interaction as moderate. Brivaracetam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness. Maprotiline also lowers the seizure threshold, which may oppose the anticonvulsant effect of brivaracetam.
How serious is the interaction between Brivaracetam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation. Consider a safer antidepressant in patients with epilepsy.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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