Drug interactions
Brivaracetam + Metaxalone
Severity: Moderate
Brivaracetam and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam commonly causes somnolence and dizziness, and metaxalone can add to these effects. Psychomotor impairment may be more pronounced when both are used.
What this interaction means in plain words
Brivaracetam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for increased drowsiness and unsteadiness. Counsel on driving and machinery precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brivaracetam and Metaxalone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metaxalone
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Metaxalone?
MediHelp rates the interaction as moderate. Brivaracetam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam commonly causes somnolence and dizziness, and metaxalone can add to these effects. Psychomotor impairment may be more pronounced when both are used.
How serious is the interaction between Brivaracetam and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and unsteadiness. Counsel on driving and machinery precautions.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
