Drug interactions
Brivaracetam + Methohexital
Severity: Moderate
Brivaracetam and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is an ultra-short-acting barbiturate anesthetic that produces profound CNS depression. Brivaracetam may add to sedation and prolong recovery or increase respiratory depression.
What this interaction means in plain words
Brivaracetam and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression; methohexital enhances GABA-A activity while brivaracetam acts through SV2A.
What to do
Titrate methohexital carefully to effect with continuous monitoring of ventilation and oxygenation. Continue brivaracetam as scheduled to avoid seizures, and anticipate slower recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Methohexital
Frequently asked questions
Can I take Brivaracetam with Methohexital?
MediHelp rates the interaction as moderate. Brivaracetam and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is an ultra-short-acting barbiturate anesthetic that produces profound CNS depression. Brivaracetam may add to sedation and prolong recovery or increase respiratory depression.
How serious is the interaction between Brivaracetam and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully to effect with continuous monitoring of ventilation and oxygenation. Continue brivaracetam as scheduled to avoid seizures, and anticipate slower recovery.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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