Drug interactions
Clemastine + Methohexital
Severity: Major
Clemastine and Methohexital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic and sedating antihistamines may deepen or prolong sedation. Respiratory depression and hypotension are possible during procedural use.
What this interaction means in plain words
Clemastine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clemastine belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression.
What to do
Titrate methohexital carefully and monitor respiration, oxygenation and blood pressure continuously. Make sure the anesthesia team knows about recent clemastine use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clemastine
Other interactions of Methohexital
Frequently asked questions
Can I take Clemastine with Methohexital?
MediHelp rates the interaction as major. Clemastine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a short-acting barbiturate anesthetic and sedating antihistamines may deepen or prolong sedation. Respiratory depression and hypotension are possible during procedural use.
How serious is the interaction between Clemastine and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully and monitor respiration, oxygenation and blood pressure continuously. Make sure the anesthesia team knows about recent clemastine use.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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