Drug interactions
Chlordiazepoxide + Methohexital
Severity: Major
Chlordiazepoxide and Methohexital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic; with a benzodiazepine, sedation and respiratory and cardiovascular depression are enhanced. Apnea and hypotension may occur at lower methohexital doses.
What this interaction means in plain words
Chlordiazepoxide and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS and respiratory depression.
What to do
Use only where airway and ventilation can be supported, and titrate methohexital to effect at reduced doses. Continuously monitor oxygenation and ventilation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Methohexital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Chlordiazepoxide
Other interactions of Methohexital
Frequently asked questions
Can I take Chlordiazepoxide with Methohexital?
MediHelp rates the interaction as major. Chlordiazepoxide and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic; with a benzodiazepine, sedation and respiratory and cardiovascular depression are enhanced. Apnea and hypotension may occur at lower methohexital doses.
How serious is the interaction between Chlordiazepoxide and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway and ventilation can be supported, and titrate methohexital to effect at reduced doses. Continuously monitor oxygenation and ventilation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
