Drug interactions
Brivaracetam + Oliceridine
Severity: Moderate
Brivaracetam and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is a potent intravenous opioid that causes sedation and respiratory depression. Brivaracetam adds to CNS depression, raising the risk of oversedation.
What this interaction means in plain words
Brivaracetam and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and brivaracetam's central effects.
What to do
Use the lowest effective oliceridine dose and monitor sedation, respiratory rate and oxygen saturation. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Brivaracetam with Oliceridine?
MediHelp rates the interaction as moderate. Brivaracetam and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is a potent intravenous opioid that causes sedation and respiratory depression. Brivaracetam adds to CNS depression, raising the risk of oversedation.
How serious is the interaction between Brivaracetam and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and monitor sedation, respiratory rate and oxygen saturation. Reduce doses if excessive sedation occurs.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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