Drug interactions
Brivaracetam + Pheniramine
Severity: Moderate
Brivaracetam and Pheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pheniramine is a first-generation antihistamine that can cause drowsiness, as can brivaracetam. Together they may increase sedation and impair alertness.
What this interaction means in plain words
Brivaracetam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Pheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from brivaracetam and the sedating antihistamine pheniramine.
What to do
Counsel patients about additive drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Pheniramine
- Amisulpride + Pheniramine Moderate
- Asenapine + Pheniramine Moderate
- Brexpiprazole + Pheniramine Moderate
- Cariprazine + Pheniramine Moderate
- Fentanyl + Pheniramine Moderate
- Levetiracetam + Pheniramine Moderate
Frequently asked questions
Can I take Brivaracetam with Pheniramine?
MediHelp rates the interaction as moderate. Brivaracetam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a first-generation antihistamine that can cause drowsiness, as can brivaracetam. Together they may increase sedation and impair alertness.
How serious is the interaction between Brivaracetam and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine if sedation is troublesome.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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