Drug interactions
Levetiracetam + Pheniramine
Severity: Moderate
Levetiracetam and Pheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pheniramine is a sedating first-generation antihistamine, and levetiracetam also commonly causes somnolence. Together they may produce greater drowsiness and impaired alertness.
What this interaction means in plain words
Levetiracetam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Pheniramine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients to avoid driving or hazardous tasks until the response is known, and consider a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Pheniramine
- Amisulpride + Pheniramine Moderate
- Asenapine + Pheniramine Moderate
- Brexpiprazole + Pheniramine Moderate
- Brivaracetam + Pheniramine Moderate
- Cariprazine + Pheniramine Moderate
- Fentanyl + Pheniramine Moderate
Frequently asked questions
Can I take Levetiracetam with Pheniramine?
MediHelp rates the interaction as moderate. Levetiracetam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a sedating first-generation antihistamine, and levetiracetam also commonly causes somnolence. Together they may produce greater drowsiness and impaired alertness.
How serious is the interaction between Levetiracetam and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks until the response is known, and consider a non-sedating antihistamine if needed.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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