Drug interactions
Cariprazine + Pheniramine
Severity: Moderate
Cariprazine and Pheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pheniramine is a first-generation sedating antihistamine, and cariprazine can also cause somnolence. Together they may produce more drowsiness and impaired performance, and anticholinergic effects can add to confusion in older adults.
What this interaction means in plain words
Cariprazine and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Pheniramine belongs to Respiratory.
Why it happens
Additive central nervous system depression from H1 antagonism and antipsychotic effects.
What to do
Warn about drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Pheniramine
- Amisulpride + Pheniramine Moderate
- Asenapine + Pheniramine Moderate
- Brexpiprazole + Pheniramine Moderate
- Brivaracetam + Pheniramine Moderate
- Fentanyl + Pheniramine Moderate
- Levetiracetam + Pheniramine Moderate
Frequently asked questions
Can I take Cariprazine with Pheniramine?
MediHelp rates the interaction as moderate. Cariprazine and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a first-generation sedating antihistamine, and cariprazine can also cause somnolence. Together they may produce more drowsiness and impaired performance, and anticholinergic effects can add to confusion in older adults.
How serious is the interaction between Cariprazine and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine, especially in older patients.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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