Drug interactions
Brivaracetam + Sparsentan
Severity: Minor
Brivaracetam and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam is partly cleared by CYP2C19, and sparsentan is a weak inducer of CYP2C19 in some data, so brivaracetam exposure could fall slightly. The clinical effect on seizure control is probably small.
What this interaction means in plain words
Brivaracetam and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brivaracetam belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Possible CYP2C19 induction by sparsentan increasing brivaracetam clearance.
What to do
Monitor seizure control when starting or stopping sparsentan. Adjust the brivaracetam dose only if breakthrough seizures occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brivaracetam
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Brivaracetam with Sparsentan?
MediHelp rates the interaction as minor. Brivaracetam and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brivaracetam is partly cleared by CYP2C19, and sparsentan is a weak inducer of CYP2C19 in some data, so brivaracetam exposure could fall slightly. The clinical effect on seizure control is probably small.
How serious is the interaction between Brivaracetam and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control when starting or stopping sparsentan. Adjust the brivaracetam dose only if breakthrough seizures occur.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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