Drug interactions
Brivaracetam + Thioridazine
Severity: Moderate
Brivaracetam and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and impaired coordination. Combined use may deepen sedation and impair psychomotor performance. Thioridazine may also lower the seizure threshold, which works against the antiseizure purpose of brivaracetam.
What this interaction means in plain words
Brivaracetam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression; thioridazine additionally lowers the seizure threshold.
What to do
Monitor for sedation and for loss of seizure control, and advise against driving until the response is known. Consider a less epileptogenic antipsychotic if seizures worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Thioridazine?
MediHelp rates the interaction as moderate. Brivaracetam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and impaired coordination. Combined use may deepen sedation and impair psychomotor performance. Thioridazine may also lower the seizure threshold, which works against the antiseizure purpose of brivaracetam.
How serious is the interaction between Brivaracetam and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for loss of seizure control, and advise against driving until the response is known. Consider a less epileptogenic antipsychotic if seizures worsen.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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