Drug interactions
Brivaracetam + Valproic acid
Severity: Minor
Brivaracetam and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so additive CNS effects may occur. Valproate does not meaningfully alter brivaracetam exposure in a way that requires dose change, although a small increase in an active metabolite has been described.
What this interaction means in plain words
Brivaracetam and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brivaracetam belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Additive CNS adverse effects; minor pharmacokinetic effects.
What to do
No dose adjustment is routinely required; monitor for sedation, dizziness and ataxia when starting or titrating either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Valproic acid?
MediHelp rates the interaction as minor. Brivaracetam and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence and dizziness, so additive CNS effects may occur. Valproate does not meaningfully alter brivaracetam exposure in a way that requires dose change, although a small increase in an active metabolite has been described.
How serious is the interaction between Brivaracetam and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required; monitor for sedation, dizziness and ataxia when starting or titrating either drug.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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